You may be eligible for the study if you meet the following criteria:

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1. Female patients from ≥18 years to 65 years of age at Screening. 

2. History of recurrent UTI defined as ≥2 UTIs in the past 6 months or ≥3 UTIs in the past 12 months prior to Screening, with at least one of these caused by E. coli based on culture results/documentation. 

3. History of positive urine culture with presence of multidrug resistant E. coli within the last 12 months. 

4. Able to supply a midstream, clean catch urine sample for microbiological analysis. 

5. Active acute uUTI infection defined by a AND b:  

a. Evidence of pyuria (presence of white blood cells in the urine):  

b. At least 2 of the following signs or symptoms of UTI

i. Dysuria (pain or burning sensation while urinating)

ii. Urinary urgency

iii. Urinary frequency

iv. Suprapubic pain (near the urinary bladder)

You are not eligible for the study if you meet the following criteria:

1. Signs or symptoms of systemic illness such as fever greater equal to or greater than 100.4°F, shaking chills, or other clinical manifestations suggestive of complicated UTI. 

2. Treatment with other antibacterial drugs including those that are effective for treatment of the acute UTI or prevention of recurrent UTI in the 3 days prior to Screening, unless the bacteria that are causing the UTI demonstrate resistance to the initial antibiotic and clinical symptoms persist.  In postmenopausal women, vaginal estrogen replacement therapy is permitted so long as all other eligibility criteria are met and the dose and regimen has be stable for > 6 months from Screening and that there are no planned changes to therapy through the 6 month follow up period.

3. Clinical symptoms for more than 4 days before Screening. 

4. Presence of indwelling urinary bladder catheters, urinary tract anatomical abnormalities, poorly controlled diabetes mellitus, immunocompromising condition and/or treatment, or advanced renal (kidney) dysfunction 

5. Individual considered to be immunocompromised.

6. Clinically significant serious unstable physical illness that in the investigator’s opinion prevents patient from completing the study. 

7. Pregnant or nursing.

8. History of autonomic dysreflexia (a condition that occurs after a spinal cord injury which results in an abnormal, overreaction of the involuntary (autonomic) nervous system to stimulation.).

9. Patients with incontinence.

10. Reside in a long-term care facility.